Award details

Cellular and molecular mechanisms controlling sensory axon growth in Drosophila

Reference	S07784
Principal Investigator / Supervisor	Professor David Shepherd
Co-Investigators / Co-Supervisors
Institution	University of Southampton
Department	Centre for Biological Sciences
Funding type	Research
Value (£)	154,820
Status	Completed
Type	Research Grant
Start date	01/09/1997
End date	01/09/2000
Duration	36 months

Abstract

This project uses targeted cell ablation and ectopic gene expression to analyse the mechanisms that control the development of sensory axons in Drosophila. The work focuses on the role of a set of embryonic sensory neurons which establish the basic framework of the adult sensory system. Evidence suggests that these neurons provide guidance cues for adult sensory axons. We will test the role by: (1) using laser ablation techniques to kill individual sensory neurons and assay the effects on the development of sensory axons. (2) using the GAL4 expression and the laser gene activation techniques to drive ectopic expression of axon guidance molecules in individual identified sensory neurons to examine the molecular basis of the guidance.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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