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Award details
Regulation of MHC class II expression on fish leucocytes
Reference
S07693
Principal Investigator / Supervisor
Professor Chris Secombes
Co-Investigators /
Co-Supervisors
Institution
University of Aberdeen
Department
Inst of Biological and Environmental Sci
Funding type
Research
Value (£)
138,668
Status
Completed
Type
Research Grant
Start date
18/08/1997
End date
18/08/2000
Duration
36 months
Abstract
Whilst MHC class I and class II genes are known to exist in fish, nothing is known about the regulation of their expression or their role in immune responses. In this application it is proposed (i) To generate monoclonal antibodies against the MHC class II beta chain (MHCIIbeta) of trout, for expression studies; (2) To analyse expression of the MHCIIbeta in trout lymphoid tissues and leucocytes; (3) To determine whether modulation of the MHCIIbeta occurs and whether it is under transcriptional or translational control; (4) To study the effects of MHCIIbeta modulation on trout specific immune responses; (5) To analyse the trout MHCIIbeta promoter for regulatory elements.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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