Award details

Melatonin the hypothalamus and seasonal timing

Reference	S07446
Principal Investigator / Supervisor	Dr Michael Hastings
Co-Investigators / Co-Supervisors	Dr David Tannahill
Institution	University of Cambridge
Department	Physiology Development and Neuroscience
Funding type	Research
Value (£)	225,410
Status	Completed
Type	Research Grant
Start date	01/12/1997
End date	30/11/2001
Duration	48 months

Abstract

Melatonin is the endocrine mediator of seasonal timing. This study will define the role of the dorsomedial nucleus of the hypothalamus as the principal target for the seasonal reproductive effects of melatonin. It will characterise melatonin-responsive cells in terms of their neurochemistry and anatomy, and define hypothalamic pathways conveying seasonal information. Anatomical studies will be facilitated by cloning of the Mel 1a receptor in the Syrian hamster. The project will also define the developmental events which regulate expression of the Mel la receptor gene. Knowledge obtained and techniques developed by the project will be directly applicable to the investigation of other aspects of melatonin signalling in the brain.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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