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A study of the mechanisms involved in the development and maintenance of hyperalgesia in sheep
Reference
S07127
Principal Investigator / Supervisor
Professor Andrea Nolan
Co-Investigators /
Co-Supervisors
Institution
University of Glasgow
Department
Department of Veterinary Pre-clinical St
Funding type
Research
Value (£)
158,587
Status
Completed
Type
Research Grant
Start date
01/12/1996
End date
01/03/2000
Duration
39 months
Abstract
Hyperalgesia, a state of increased responsiveness to noxious stimuli, is of major welfare importance and its occurrence has been documented in sheep with acute and chronic inflammatory disease. The non-steroidal anti-inflammatory drugs, drugs which inhibit cyclooxygenase enzymes, have been shown to reverse a hyperalgesia both in rodents and in sheep. However, these drugs have toxic side-effects probably associated with their effects on COX-1. It is proposed to identify the role of COX-1 and COX-2 in hyperalgesia in sheep and investigate interactive links with other known mediators of hyperalgesia. In addition, the significance of the induction of tachyphylaxis to hyperalgesia, first recorded in sheep, will be assessed.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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