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Early strain-related control mechanisms in bone's functionally adaptive response to load-bearing
Reference
S06814
Principal Investigator / Supervisor
Professor Lance Lanyon
Co-Investigators /
Co-Supervisors
Professor Andrew Pitsillides
Institution
Royal Veterinary College
Department
Veterinary Basic Sciences - London
Funding type
Research
Value (£)
147,989
Status
Completed
Type
Research Grant
Start date
01/09/1997
End date
01/09/2000
Duration
36 months
Abstract
The mechanism by which bone cells' early responses to strain are translated into the coherent stimulus responsible for controlling bone's architectural adjustments, to ensure fracture resistance, will be established. By loading ulnar explants, and monolayers of purified osteocytes and osteoblast-like cells, in parallel with in vivo loading of rat ulnae, we will investigate whether strain is quantified by Ca2+ traffic through ion channels; the role of strain-related NO and PG production; their inter-relationship and influence on IGF synthesis and (re)modelling; whether NOS expression is controlled by strain history; and the possibility of increasing osteogenic responses to loading by dietary supplementation with gamma- linolenic acid.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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