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Quantitative investigation of the synaptic conductances and connectivity in a vertebrate spinal pattern generator
Reference
S06745
Principal Investigator / Supervisor
Professor Nicholas Dale
Co-Investigators /
Co-Supervisors
Institution
University of St Andrews
Department
Biology
Funding type
Research
Value (£)
161,232
Status
Completed
Type
Research Grant
Start date
22/10/1996
End date
31/01/2000
Duration
39 months
Abstract
Spinal circuits of vertebrates consist of large interconnected neural populations. Although qualitative descriptions of spinal circuitry exist, precise information about the frequency and distribution of synapses necessary to understand, for example, longitudinal coordination of locomotion is absent. I shall study the locomotor circuitry of Xenopus embryos by making patch clamp recordings from the intact spinal cord. For each component of the locomotor synaptic drive, I will: measure its magnitude and kinetics; obtain the quantal content and number of active and inactive presynaptic neurons; and study its rostro-caudal distribution. I will thus be able formulate quantitative rules to describe synaptic connectivity within the spinal cord.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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