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Molecular basis of Th subset bias in intestinal nematode infections
Reference
S06692
Principal Investigator / Supervisor
Professor Richard Michael Maizels
Co-Investigators /
Co-Supervisors
Institution
University of Edinburgh
Department
Inst of Cell, Animal and Population Biol
Funding type
Research
Value (£)
202,632
Status
Completed
Type
Research Grant
Start date
01/04/1997
End date
01/04/2000
Duration
36 months
Abstract
Parasitic helminths are potent drivers of the T-helper type 2 (Th2) subset of lymphocytes. Th2 cytokines generate the exaggerated IgE and eosinophil responses observed in all animal host species infected with nematodes. We plan to identify novel mediators secreted by the rodent parasite Nippostrongylus brasiliensis which activate the Th2 pathway, and to define the primary host cells responding to these molecules. Secreted products will be characterised structurally and tested individually for immunological effects. These studies may identify a natural Th2 adjuvant of broad significance to immunology and animal health.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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