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Molecular mechanisms of action of black widow spider toxins
Reference
S06591
Principal Investigator / Supervisor
Dr David Bell
Co-Investigators /
Co-Supervisors
Dr Ian Duce
,
Professor Peter Norman Russell Usherwood
Institution
University of Nottingham
Department
Sch of Biosciences
Funding type
Research
Value (£)
274,526
Status
Completed
Type
Research Grant
Start date
05/11/1996
End date
03/05/2000
Duration
42 months
Abstract
We have recently cloned delta-latroinsectotoxin, an insect-specific toxin from black widow spider venom, and expressed the protein as a function toxin in E. coli (ref 1). This project will use molecular biology techniques to identify structural features of the toxin governing its toxicology and electrophysiology in locust motor nerve terminals. The use of delta- latroinsectotoxin mutants with defined functions will be invaluable for investigating the site and mode of action of this toxin, and illuminating the mechanisms controlling neurotransmitter release from motor nerve terminals.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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