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Award details
Identification of virulence genes in Mycobacterium paratuberculosis by allelic exchange
Reference
S06531
Principal Investigator / Supervisor
Professor Johnjoe McFadden
Co-Investigators /
Co-Supervisors
Institution
University of Surrey
Department
Health and Medical Sciences
Funding type
Research
Value (£)
186,392
Status
Completed
Type
Research Grant
Start date
01/09/1996
End date
01/10/2000
Duration
50 months
Abstract
Paratuberculosis causes a chronic enteritis of ruminants that is responsible for considerable economic losses to the livestock industry world-wide. Little is known concerning pathogenesis of the disease and effective vaccines are not available. This project aims to develop genetic systems to identify virulence genes in Mycobacterium paratuberculosis. Knock-out mutants of M. paratuberculosis will be constructed by allele replacement of potential virulence genes. The virulence characteristics of M. paratuberculosis mutants will be investigated by 1) examination of growth in macrophages and 2) virulence for experimental animal at MRI. The products of virulence genes may be further developed as components of subunit vaccines. Knock- out M. paratuberculosis mutants may form the basis of new attenuated vaccines for paratuberculosis.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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