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Characterisation of African swine fever virus encoded genes which modulate the host immune response
Reference
S06519
Principal Investigator / Supervisor
Dr Linda Dixon
Co-Investigators /
Co-Supervisors
Dr Michael Parkhouse
,
Dr Penelope Powell
Institution
The Pirbright Institute
Department
Div of Molecular Biology
Funding type
Research
Value (£)
167,011
Status
Completed
Type
Research Grant
Start date
01/11/1996
End date
01/11/1999
Duration
36 months
Abstract
We propose to study two African swine fever virus (ASFV) encoded genes which are likely to dramatically modulate the host immune response. We will investigate the effect of these virus encoded genes on specific immune responses, the mechanism by which the encoded proteins function and the effect of these genes on ASFV pathogenesis in pigs. One gene (A238L) is similar to an inhibitor (IkB)of the host transcription factor NFkB and we shall define how this interferes with NFkB activation and subsequent transcription of genes coding for proinflammatory cytokines. The second gene (EP402R) is similar to an important regulatory T- cell surface protein, CD2 which mediates or enhances T-cell activation via interactions with CD58. We shall investigate the possibility that expression of this viral CD2 homologue interferes with CD58 mediated immune mechanisms.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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