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The role of exogenous Jaagsiekte sheep retrovirus (JSRV) in the aetiology of sheep pulmonary adenomatosis
Reference
S06361
Principal Investigator / Supervisor
Dr Robert Dalziel
Co-Investigators /
Co-Supervisors
Institution
University of Edinburgh
Department
Veterinary Pathology
Funding type
Research
Value (£)
186,627
Status
Completed
Type
Research Grant
Start date
06/01/1997
End date
30/09/2000
Duration
56 months
Abstract
SPA has been identified as one of the most important infectious diseases of adult sheep and also poses a threat to trade in live sheep. The economic and welfare considerations illustrate the urgent need to understand the pathogenesis of SPA and control and prevention measures cannot be devised until the aetiologic agent is unambiguously determined. The aim of this project is to test the hypothesis that exJSRV induces tumours by insertional mutagenesis, proof of this hypothesis will provide conclusive evidence of the role of JSRV in SPA. We will characterise exJSRV integration loci to determine if common integration loci exist in different tumours and identify virally induced alterations in cellular gene expression.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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