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The role of parasite acetylcholinesterases in Dictyocaulus viviparus infection in cattle
Reference
S06353
Principal Investigator / Supervisor
Professor Jacqueline Matthews
Co-Investigators /
Co-Supervisors
Professor Andrew Tait
Institution
University of Liverpool
Department
Veterinary Clinical Science
Funding type
Research
Value (£)
111,284
Status
Completed
Type
Research Grant
Start date
10/06/1996
End date
10/07/1999
Duration
37 months
Abstract
This project aims to elucidate the role and immunogenicity of acetylcholinesterases (AChEs) secreted by adult D. viviparus. To provide sufficient enzyme for the analyses, the gene(s) encoding the parasite AChE(s) will be cloned by a combination of PCR and expression library screening. Experiments will be performed to examine if the parasite AChE has an inhibitory effect on Ach-stimulated bovine lymphocytes. An immunisation experiment will be performed in which the protective capacity of cloned AChE will be compared with that of adult ES products and L3 infection. Lymphocyte proliferative, cytokine and antibody responses will be assessed in the different groups. The studies will determine the possible roles of AChE in this host: parasite interaction.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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