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Award details
To define the biological and molecular properties of cattle dendritic cells
Reference
S06104
Principal Investigator / Supervisor
Professor Joe Brownlie
Co-Investigators /
Co-Supervisors
Institution
Royal Veterinary College
Department
Pathology and Pathogen Biology
Funding type
Research
Value (£)
228,018
Status
Completed
Type
Research Grant
Start date
01/01/1997
End date
01/03/2000
Duration
38 months
Abstract
This project will define the biological and molecular properties of dendritic cells found in lymph - afferent lymph veiled cells (ALVC). Preliminary studies show two novel phenotypic populations of ALVC based on Mab staining of surface antigens, particularly CD 11a+/11a- and other molecules. Their biological properties will be defined based on macropinocytosis, presentation of exogenous and endogenous antigen and their in vivo location with lymphoid tissues. The influence of viral infection on the phenotypic expression and biological functions of ALVC will be examined in cells infected both in vitro with BVDV persistently-infected animals.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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