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The regulation of the mammalian pineal gland by light; the use of retinally degenerate mouse models
Reference
S06023
Principal Investigator / Supervisor
Professor Russell Foster
Co-Investigators /
Co-Supervisors
Institution
Imperial College London
Department
Biological Sciences
Funding type
Research
Value (£)
132,992
Status
Completed
Type
Research Grant
Start date
01/05/1996
End date
01/05/1999
Duration
36 months
Abstract
Environmental light-dark cycles determine the pattern of melatonin secretion from the pineal. However, the photoreceptors that regulate this neuroendocrine pathway remain unidentified. A recent report has shown that light-suppression of melatonin remains intact in certain groups of sightless people. These findings are strikingly similar to our studies in rodents showing that the retinal pathway that regulates circadian behaviour is distinct from the pathway involved in visual perception. Using retinally degenerate mouse models we address two related questions: 1) Which retinal photoreceptors regulate pineal melatonin synthesis? and 2) Does the photic regulation of the pineal differ from the regulation of circadian behaviour?
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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