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Coordinate action of oxytocin in the limbic system: importance for regulating peripartum neuroendocrine activity
Reference
S06012
Principal Investigator / Supervisor
Professor Colin Ingram
Co-Investigators /
Co-Supervisors
Institution
University of Bristol
Department
Anatomy
Funding type
Research
Value (£)
134,911
Status
Completed
Type
Research Grant
Start date
01/03/1996
End date
01/12/1999
Duration
6 months
Abstract
Current studies indicate a role for oxytocin (OT) in coordinating adaptive events associated with parturition and lactation through its action on limbic neurones. It is proposed that temporal patterns of receptor expression ensure that different populations are activated in an appropriate sequence. This will be investigated by: (i) electrophysiology combined with autoradiography to examine changing of receptor expression; (ii) electrophysiological and tracing techniques to demonstrate connectivity between OT-sensitive populations; (iii) peptide infusions and neurochemical lesions to study functional importance of each population for parturition and milk ejection. This will offer a model system of coordinate neuropeptide action within the limbic system.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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