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Pharmacological modulation of electrical potentials recorded from Caenorhabditis elegans pharyngeal muscle

Reference	S05805
Principal Investigator / Supervisor	Professor Lindy Holden-Dye
Co-Investigators / Co-Supervisors	Professor Robert J. Walker
Institution	University of Southampton
Department	Centre for Biological Sciences
Funding type	Research
Value (£)	105,001
Status	Completed
Type	Research Grant
Start date	01/05/1996
End date	01/05/1999
Duration	36 months

Abstract

This study has been prompted by lack of functional information on the nematode C. elegans, despite the rapidly expanding genetic information. The applicants have expertise in the study of nematode physiology and pharmacology and propose to extend this to a study of the pharyngeal muscle of C. elegans. Electrical potentials will be recorded from wild-type worms and characterised in terms of modulation by ion channel blockers and putative neurotransmitters. This approach will then be used for the pharmacological analysis of C. elegans mutants, and thus provide a powerful technique for characterising mutant phenotypes.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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