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Intra-ovarian roles of activins inhibins and follistatin in follicular development in cattle
Reference
S05760
Principal Investigator / Supervisor
Professor Philip Knight
Co-Investigators /
Co-Supervisors
Institution
University of Reading
Department
Animal and Microbial Sciences
Funding type
Research
Value (£)
159,830
Status
Completed
Type
Research Grant
Start date
01/12/1996
End date
01/12/1999
Duration
36 months
Abstract
Novel immunoassays will be used to investigate factors (i.e. growth factors, gonadotrophins, steroids) regulating differential production of activin (betaAbetaA), inhibin (alphabetaA) and follistatin by bovine whole-follicle cultures and isolated granulosa cells. Expression of mRNA for alpha and betaA subunits, follistatin and activin receptors will be evaluated by in situ hybridisation. The use of activin receptor antibodies to block potential autocrine effects of activin will be studied. The ability of antisense oligos targeted at alpha, betaA and follistatin mRNAs, to suppress synthesis of activin, inhibin and follistatin and perturb cell function will also be explored. Activin, inhibin and follistatin will be measured for the first time in individual bovine follicles from early antral through to dominant ovulatory/subordinate/atretic stages.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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