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Hormonal regulation of osteocyte gene expression in vivo
Reference
S05008
Principal Investigator / Supervisor
Professor T M Skerry
Co-Investigators /
Co-Supervisors
Institution
University of York
Department
Biology
Funding type
Research
Value (£)
112,888
Status
Completed
Type
Research Grant
Start date
01/04/1996
End date
01/04/1998
Duration
24 months
Abstract
Evidence is increasing that osteocytes are involved in regulation of bone mass. They have gap junctions, oestrogen and parathyroid hormone receptors and respond to loads. (Expression of functional PTH receptors by osteocytes in vivo is one finding of a current BBSRC project). Using a novel method to isolate mRNA from osteocytes and to investigate gene expression using differential display PCR, we have identified osteocyte genes regulating loading. This project will investigate the effects of ovariectomy and parathyroidectomy on osteocyte gene expression in vivo using DDPCR, Northern blotting and in situ hybridisation. Results from these experiments will have implications in diseases in man and animals where bone is lost and fractures occur.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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