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Regulation of foetal Leydig cell and Sertoli cell development

Reference	S04871
Principal Investigator / Supervisor	Professor Peter O'Shaughnessy
Co-Investigators / Co-Supervisors
Institution	University of Glasgow
Department	Department of Veterinary Pre-clinical St
Funding type	Research
Value (£)	155,754
Status	Completed
Type	Research Grant
Start date	06/11/1995
End date	06/11/1998
Duration	36 months

Abstract

Establishment of an active population of Sertoli cells and Leydig cells is vital for normal male development and fertility. Alterations in cell number or activity during development may have profound effects on subsequent fecundity of the adult animal. Nevertheless, mechanisms which control fetal development of these cells remain unclear. It is proposed to use mutant mouse strains to examine factors regulating the proliferation and function of fetal Leydig cells and Sertoli cells. Cell number and function will be measured during fetal development in normal animals and in animals lacking gonadotrophins or androgen receptors. These studies will reveal the role of the gonadotrophins and androgens in regulating fetal testicular development.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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