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Characterisation of the nicotinic acetylcholine receptors from Manduca sexta

Reference	S04248
Principal Investigator / Supervisor	Dr Adrian John Wolstenholme
Co-Investigators / Co-Supervisors	Professor Stuart Reynolds, Ms Sue Wonnacott
Institution	University of Bath
Department	Biology and Biochemistry
Funding type	Research
Value (£)	193,582
Status	Completed
Type	Research Grant
Start date	01/06/1994
End date	01/04/1998
Duration	46 months

Abstract

1) To obtain cDNA clones encoding nicotinic acetylcholine receptors from Manduca sexta. 2) To express these clones and pharmacologically characterise the receptors they encode, especially the response to nicotine. 3) To identify specific amino acid residues involved in any distinctive pharmacology of the Manduca nAchR. 4) To examine the temporal and spatial control of receptor expression in the intact insect.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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