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Nutrient signals regulating muscle hormone sensitivity in ruminants

Reference	S04008
Principal Investigator / Supervisor	Professor Michael Lomax
Co-Investigators / Co-Supervisors
Institution	University of Aberdeen
Department	Agriculture and Forestry
Funding type	Research
Value (£)	275,705
Status	Completed
Type	Research Grant
Start date	01/10/1995
End date	24/06/1999
Duration	45 months

Abstract

Changing the sensitivity of tissues to hormones is a key physiological mechanism which may be of more importance than alterations in plasma hormone concentrations. It has been demonstrated that specific amino acids act as signals or modulators to increase muscle protein synthesis responses to insulin. We propose to examine the importance of nutrient signals in changing hormone sensitivity by testing the hypothesis that amino acids selectively alter the sensitivity of muscle protein turnover to anabolic hormones in ruminants and that the mechanism for changes in protein synthesis is via an increase in the efficiency of translation. Protein turnover across the tissues of the hindlimb will be measured using arterio-venous difference, kinetic isotope transfer and blood flow rate techniques during close arterial infusions of anabolic hormones and amino acids. Application of local treatments directly at the tissue bed will enable the use of contralateral hindlimb to act as a control for each treatment. The results will provide fundamental knowledge on the hormonal sensitivity of protein turnover and provide insight into new ways to optimise lean tissue growth in cattle.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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