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Nutrient and hormonal effects on the expression of genes of the porcine growth hormone-IGF axis
Reference
S04003
Principal Investigator / Supervisor
Professor Peter Buttery
Co-Investigators /
Co-Supervisors
Institution
University of Nottingham
Department
Sch of Biosciences
Funding type
Research
Value (£)
158,125
Status
Completed
Type
Research Grant
Start date
01/04/1995
End date
01/04/1998
Duration
36 months
Abstract
It is proposed to exploit an established porcine primary hepatocyte culture system to investigate the direct effects of nutrients alone and in combination with hormones on the expression of the growth hormone receptor (GHR), insulin-like growth factor-I (IGF-I) and insulin-like growth factor binding protein-1) (IGFBP1) genes. Using methods which measure steady state levels of cytoplasmic mRNA, nuclear transcription rates of mRNA and DNA- protein interactions on the gene promoters, we propose to establish whether the three genes are affected directly by nutrition and if so which regulatory pathways might be involved. It would then be established whether these mechanisms operate in vivo, employing controlled feeding trials with pigs.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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