Award details

The functional role of interleukin-9 (IL-9) in immunity

Reference	S03928
Principal Investigator / Supervisor	Professor Richard Grencis
Co-Investigators / Co-Supervisors
Institution	The University of Manchester
Department	Life Sciences
Funding type	Research
Value (£)	146,790
Status	Completed
Type	Research Grant
Start date	30/10/1995
End date	29/10/1998
Duration	36 months

Abstract

The aim of the present proposal is to define the functional role which IL-9 plays in vivo. Using a well established model of intestinal helminth infection we have preliminary data showing for the first time evidence of a definite role for IL-9 in the potentiation of Th2 responses in vivo. We will use this model in conjunction with manipulation of IL-9 levels in vivo through administration of cytokines, monoclonal antibodies and the use of transgenic animals to confirm and extend these results. The data generated will have important implications not only for host protective immunity to helminths but also in immunopathological conditions such as allergy and allergic asthma in which a prolonged and sustained Th2 response is observed.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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