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Analysis of the replication of the avian coronavirus infectious bronchitis virus (IBV)
Reference
S03905
Principal Investigator / Supervisor
Dr Thomas David Kay Brown
Co-Investigators /
Co-Supervisors
Professor Ian Brierley
Institution
University of Cambridge
Department
Pathology
Funding type
Research
Value (£)
15,178
Status
Completed
Type
Research Grant
Start date
01/05/1995
End date
01/05/1998
Duration
36 months
Abstract
A programme for the study of avian coronavirus IBV replication is described. RNA- dependent polymerase (1a/b) polyprotein) function will be studied with emphasis on polyprotein processing and on functional studies using expression of 1a/b to replicate and transcribe defective RNAs containing appropriate cis-acting signals. Genetic manipulation of IBV using recombination of synthetic defective RNAs will be developed and the ability of T7 transcription systems to produce 27.6kb RNA required for infectious cDNA clone systems will be tested. The role of the long 5' UTR of IBV genomic RNA in its translational initiation will be studied.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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