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Neuronal targets of the NO-cGMP signalling pathway
Reference
S03858
Principal Investigator / Supervisor
Professor Maurice Elphick
Co-Investigators /
Co-Supervisors
Institution
Queen Mary University of London
Department
Sch of Biological and Chemical Sciences
Funding type
Research
Value (£)
163,971
Status
Completed
Type
Research Grant
Start date
01/09/1995
End date
01/09/1998
Duration
36 months
Abstract
The aim is to identify the neuronal targets of the gaseous signalling molecule nitric oxide (NO) in the nervous system of an insect (Schistocerca gregaria). This will be achieved by localising anatomically the NO receptor (soluble guanylyl cyclase) and its product cyclic GMP using immunocytochemistry and in situ hybridisation. This will provide the first insight into the neuroanatomy of NO-cGMP signalling in an invertebrate nervous system. Moreover, it will identify neurons in which the physiological roles of NO can be explored. Data obtained may also provide the basis for development of novel insecticides.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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