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Sex steroid-dependent modulation of signalling by noradrenergic neurones
Reference
S03833
Principal Investigator / Supervisor
Professor John Russell
Co-Investigators /
Co-Supervisors
Professor Gareth Leng
Institution
University of Edinburgh
Department
Biomedical Sciences
Funding type
Research
Value (£)
172,710
Status
Completed
Type
Research Grant
Start date
01/12/1995
End date
31/05/2000
Duration
54 months
Abstract
Brainstem noradrenergic neurones provide a major innervation of the neuroendocrine hypothalamus. Subpopulations contain different co-existing peptides, and many concentrate oestrogen. Different subsets serve separate roles in neuroendocrine regulation; our hypothesis is that sex steroids modulate these roles by changes in the expression of co-secreted peptides. Retrograde tracing will neuroanatomically define subpopulations projecting to the supraoptic nucleus which differentially regulate oxytocin and vasopressin secretion; combined immunocytochemistry or in situ hybridisation will differentiate phenotypes, and modulation by sex steroids. Using microdialysis and electrophysiology we will study the functional significance of peptide co-secretion.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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