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The role of titin in muscle: a gene targeting approach
Reference
S03806
Principal Investigator / Supervisor
Professor Michelle Peckham
Co-Investigators /
Co-Supervisors
Institution
University of Leeds
Department
Human Biology
Funding type
Research
Value (£)
180,052
Status
Completed
Type
Research Grant
Start date
17/07/1995
End date
30/11/1998
Duration
41 months
Abstract
Titin is a large (3,000,000D, 90kb coding sequence) protein found in muscle, probably essential for organising the thick filament into muscle sarcomeres, regulating its length and centering it in the sarcomere during contraction. We plan to use a novel myogenic tissue culture system that is ideal to investigate how titin does this. The myogenic cells fuse into myotubes that express titin, form well developed sarcomeres, and can be used for mechanical measurements and light and electron microscopy. We will make mutations in titin by gene targeting and study their effects in the myotubes by mechanics and microscopy.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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