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The role of B-lymphocytes in the pathogenesis of a natural gamma-herpes virus infection

Reference	S02646
Principal Investigator / Supervisor	Professor Anthony Nash
Co-Investigators / Co-Supervisors
Institution	University of Edinburgh
Department	University of Edinburgh Department
Funding type	Research
Value (£)	206,947
Status	Completed
Type	Research Grant
Start date	01/09/1994
End date	01/11/1997
Duration	38 months

Abstract

Murine herpesvirus-68 (MHV-68) is a B-cell tropic gammaherpesvirus and a natural infection of small rodents. Studies on this virus have already revealed similarities to the infection and pathogenesis of other gammaherpesviruses of man and domestic animals. In this project we plan to investigate the consequences of the interaction between B-cells and MHV-68 in vivo. The study will involve an analysis of (a) the course of MHV-68 infection in B-cell -ve mice (mu-chain deficient transgenics, which lack mature B-cells), (b) the fate of infected B-cells transferred to B-cell -ve mice, in particular the longevity of the cells and their ability to progress to lymphoproliferative disease and (c) a comparison of the T-cell response in B-cell +ve and B-cell -ve mice. We anticipate these studies will provide important basic information on the natural history of gammaherpesvirus infection of man and domestic animals.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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