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Morphogenesis of bluetongue and related orbiviruses

Reference	S01870
Principal Investigator / Supervisor	Professor Polly Roy
Co-Investigators / Co-Supervisors
Institution	University of Oxford
Department	Laboratory of Molecular Biophysics
Funding type	Research
Value (£)	414,189
Status	Completed
Type	Research Grant
Start date	04/10/1994
End date	31/03/2000
Duration	66 months

Abstract

The overall objective of the programme is to understand the morphogenesis and complete assembly processes of BTV as an example of a complex non-enveloped RNA virus of veterinary importance. This will be investigated by defining the essential morphogenetic interactions of viral components (7 structural proteins, VP1-7 and 10 dsRNA genome) and how the four viral non-structural proteins are involved in the BTV replication process. To achieve these goals we will use systems that we have established which allow us to produce and manipulate in vitro and in vivo structural entities representing BTV. Procedures will be developed to encapsulate the viral genome into the derived core-like and virus-like particles and to establish a viral RNA replication system. The results and systems that are established will eventually allow us to determine if these events can be selectively inhibited by defective analogues of the viral macromolecules.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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