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The role of N-(3-oxohexanoyl) homoserine lactone in regulating the secondary metabolism and virulence of Aeromonas species
Reference
S01755
Principal Investigator / Supervisor
Dr G Stewart
Co-Investigators /
Co-Supervisors
Professor Paul Williams
Institution
University of Nottingham
Department
Sch of Biosciences
Funding type
Research
Value (£)
147,382
Status
Completed
Type
Research Grant
Start date
01/10/1994
End date
01/10/1997
Duration
36 months
Abstract
Aeromonas hydrophilia and Aeromonas salmonicida are important pathogens of both humans and fish which produce extracellular virulence factors including haemolysins, cytotoxins and proteases. At the University of Nottingham we have discovered that both species of Aeromonas produce N-(3-Oxohexanoyl) homoserine lactone (HSL), a signalling molecule that controls the expression of extracellular virulence determinants in Pseudomonas and Erwinia. We propose to define at the molecular level the basis of HSL production in Aeromonas and to study in detail both the regulatory genes and structural genes from HSL regulated operons. This programme will provide entirely novel insights into the expression of Aeromonas virulence determinants and will present new opportunities for biological control of the organism.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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