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The proton conductance of liposomes made from mitochondrial phospholipids of animals with different metabolic rates
Reference
S01557
Principal Investigator / Supervisor
Professor Martin Brand
Co-Investigators /
Co-Supervisors
Institution
University of Cambridge
Department
Biochemistry
Funding type
Research
Value (£)
171,509
Status
Completed
Type
Research Grant
Start date
01/10/1994
End date
01/10/1997
Duration
36 months
Abstract
Mitochondrial proton leak is a significant contributor to metabolic rate. Both metabolic rate and proton leak increase in smaller animals, in hyperthyroidism and in mammals compared to reptiles. Particular phospholipid side changes are associated with these increases. We will test whether changes in phospholipid cause the changes in proton leak (and metabolic rate) by seeing whether the proton conductance of liposomes made from mitochondrial inner membrane phospholipids varies in the same way as conductance of the original mitochondria. We will separate phospholipid types and test which are important and will identify which fatty acid side chains increase and which decrease liposome proton conductance.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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