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The role of cortisol in the perinatal IGF switch in fetal sheep: implications for growth and maturation
Reference
S01387
Principal Investigator / Supervisor
Professor Abigail Fowden
Co-Investigators /
Co-Supervisors
Institution
University of Cambridge
Department
Physiology
Funding type
Research
Value (£)
189,193
Status
Completed
Type
Research Grant
Start date
01/12/1993
End date
31/12/1997
Duration
49 months
Abstract
In the early life, changes in growth and its regulatory mechanisms have major consequences for the efficiency of animal production and the etiology of adult disease. Thus, the main aims of the study are to determine the role and molecular actions of cortisol in the perinatal switch from IGF-II to IGF-I production and to identify whether changes in cortisol during undernutrition activate this switch prematurely in foetal sheep. Gene expression of IGF-I, -II and GH receptors will be examined in various tissues from intact fetuses of well-fed and undernourished ewes and from foetuses with cortisol levels manipulated by fetal adrenalectomy and cortisol infusion. Growth rates will also be measured in these foetuses to determine the importance of cortisol in prepartum growth.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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