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Cyclic AMP-dependent protein kinase structure, function and regulation in mammary gland during pregnancy and lactation
Reference
S01106
Principal Investigator / Supervisor
Dr Mike Munday
Co-Investigators /
Co-Supervisors
Institution
University College London
Department
Dept of Pharmaceutical and Biological Ch
Funding type
Research
Value (£)
188,426
Status
Completed
Type
Research Grant
Start date
04/10/1993
End date
31/05/1997
Duration
43 months
Abstract
Tissue-specific hormonal responses are associated with atypical properties of cAMP-dependent protein kinase (cAMP-PK) in mammary gland. We aim to characterise the molecular basis for the uniqueness of mammary cAMP-PK by : (1) Determination of the primary structure of its catalytic subunit and comparison of the C subunit structure and properties with those of known isozymes. (2) Identification and structural analysis, via copurification and related techniques, of C subunit-specific binding proteins and activity modulating factors unique to this tissue. (3) Measurement, using cDNA probes and antibodies, of C subunit and modulator mRNA and protein expression throughout pregnancy and lactation and in response to hormonal manipulation.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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