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X-ray diffraction equipment for high-throughput protein crystallography in biological research

Reference	REI20559
Principal Investigator / Supervisor	Professor Neil William Isaacs
Co-Investigators / Co-Supervisors
Institution	University of Glasgow
Department	School of Chemistry
Funding type	Research
Value (£)	200,000
Status	Completed
Type	Research Grant
Start date	01/03/2004
End date	28/02/2007
Duration	36 months

Abstract

X-ray diffraction equipment consisting of a high brilliance, microfocus X-ray generator, confocal x-ray optics and dual image plate detector will support a broad range of structural biology research in the new Biomolecular Research Centre at the University of Glasgow. This new building will house over 300 research staff drawn from departments and divisions inthe Physical Sciences, Biological Sciences and Medical Faculties of the University. The programme of research will have a considerable component related to studies on integral membrane proteins. This will include continuing work on photosynthetic units (light-harvesting complexes and reaction centres) from photosynthetic bacteria. As well as revealing the functional mechanisms of these complexes in detail, the studies are generating new insight into the interactions between protein and lipid in the cell membrane. The Beta-chemokine receptor D6 (a G-protein coupled receptor) and the bacterial autotransporter proteins are new integral-membrane protein targets where successful structure determinations will have a considerable scientific impact. Studies on bacterial pathogens and virulence factors draw together investigators from microbiology and protein crystallography with the potential outcome of defining new targets for therapeutic control of bacterial infections. Other studies on enzymes from metabolic pathways will provide other targets for intervention. The proposed studies are not limited to bacterial systems. The University of Glasgow has strong research activities in parasitology and immunology and a number of planned projects will link up with research in these disciplines. A notable feature of the proposed research is the close collaboration between protein crystallographers and clinical research.

Summary

unavailable

Committee	Closed Committee - Biomolecular Sciences (BMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Research Equipment Initiative 2003 (RE2) [2003]
Funding Scheme	X – not Funded via a specific Funding Scheme

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