Award details

Reliable quantification of nucleic acids and proteins in liquid and solid phase

Reference	REI20528
Principal Investigator / Supervisor	Professor Alastair Goldman
Co-Investigators / Co-Supervisors	Professor Simon J. Foster, Professor Julie Gray, Professor J Green, Krebs Professor of B Christopher Hunter, Professor Dave Kelly, Professor Anne Moir, Dr Lynda Partridge, Professor Robert K Poole, Professor Peter Edwin Sudbery, Dr Donald Jeremy Watts, Professor Stuart Wilson
Institution	University of Sheffield
Department	Molecular Biology and Biotechnology
Funding type	Research
Value (£)	68,201
Status	Completed
Type	Research Grant
Start date	01/09/2003
End date	31/08/2004
Duration	12 months

Abstract

The research proposed here cuts across a very wide section of Molecular Biology and Biotechnology Department at Sheffield. Quantification of biomaterials in either or both of solid and liquid phases is central to projects for all 12 applicants. Accurate quantification in modern molecular biology is an essential tool required to understand the complex process and interactions understudy. Eukaryotic and prokaryotic model organisms will be used to increase our understanding of many biological processes including; DNA repair, regulation of protein abundance, protein modification, mRNA processing, response to environmental stress, energy transfer, cell wall synthesis, solute transport, spore formation and germination, membrane organisation and plant development. The range of organisms in use includes important pathogens such as S. aureus, C. jejuni, B. cereus, S. typhimurium and C. albicans. Work in other systems also tackles issues related to human health, including immunology, reproduction and development. Outside the areas directly related to human health are plant biology and photosynthesis, issues of important economic interest. Of the 12 applicants 11 are supported by BBSRC with currents of over £8M, plus many BBSRC graduate studentships. The work listed here contributes significantly towards BBSRC sponsored projects. Obtaining centralised facilities that are essential to further these projects will encourage even greater interaction between the groups and ultimately enhance their ability of make best use of BBSRC funding in hand.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Research Equipment Initiative 2003 (RE2) [2003]
Funding Scheme	X – not Funded via a specific Funding Scheme

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