Award details

Translational research in gene delivery/gene therapy and pharmacogenomics

Reference	REI18501
Principal Investigator / Supervisor	Professor Leonard Seymour
Co-Investigators / Co-Supervisors	Professor David Kerr, Dr Robert Walton
Institution	University of Oxford
Department	Oncology
Funding type	Research
Value (£)	26,508
Status	Completed
Type	Research Grant
Start date	01/04/2003
End date	31/01/2004
Duration	10 months

Abstract

The purchase of an ABI PRISM Sequence Detector (Quantitative PCR Machine) will supplement analytical equipment available within the newly-commissioned Department of Clinical Pharmacology, and will be heavily used in a range of science-led basic and translational research projects in fields closely related to BBSRCs priority interests. The equipment will initially be used in two main fields: (i) Measurement of genomes of vectors for gene delivery/therapy. This will enable determination of - distribution kenetics, specific transduction activity and quantification of virus replication; (ii) Detection of single nucleotide polymorphisms in target genes associated with specific responses to treatment. This is a growing field where applications will proliferate. At present we plan three types of study: quantitate levels of allele-specific mRNA, seek to correlate responses to anticancer drugs, perform extensive pharmacogenetic typing in studies developing cyclo-oxygenase 2 inhibitors. The Q- PCR machine will also find other applications, although all will be within BBSRCs field of priority of Exploiting Genomics. The fields of gene delivery/gene therapy and pharmacogenomics reflect key areas of progress in this discipline, and will form the backbone of research in this new department.

Summary

unavailable

Committee	Closed Committee - Engineering & Biological Systems (EBS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Research Equipment Initiative 2002 (REI) [2002]
Funding Scheme	X – not Funded via a specific Funding Scheme

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