Award details

Behaviour and modification of nanosystems of customised nanosystems for drug-gene and vaccine delivery

Reference	REI18499
Principal Investigator / Supervisor	Dr Alexander Florence
Co-Investigators / Co-Supervisors	Professor Oya Alpar, Professor Ian Kellaway, Dr Sakthivel Thiagarajan
Institution	University College London
Department	Centre for Drug Delivery Research
Funding type	Research
Value (£)	91,500
Status	Completed
Type	Research Grant
Start date	23/12/2002
End date	23/12/2005
Duration	36 months

Abstract

The design and use of nanoparticulate carrier systems for drug, gene and vaccine delivery is driven by the desire to obtain systems of unique and small size to allow the more effective extravasation from the circulation, uptake from sites delivery such as the GI tract and penetration through tissues. If particles do not retain their individual status through aggregation, association with proteins or other biological molecules, or through flocculation in media for cell culture or in vivo after administration, the goals of targeting can be frustrated. This application makes a case for the purchase of an instrument newly available, using the field flow fractionation (FFF) technique, which allows the study of the size of colloidal systems in the range of 1 nm to 1000 nm.

Summary

unavailable

Committee	Closed Committee - Engineering & Biological Systems (EBS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Research Equipment Initiative 2002 (REI) [2002]
Funding Scheme	X – not Funded via a specific Funding Scheme

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