Award details

High sensitivity maximum throughput metabolite profiling

Reference	REI18489
Principal Investigator / Supervisor	Professor Jeffrey Graham Duckett
Co-Investigators / Co-Supervisors	Professor Jane Thomas-Oates, Professor Anthony Wilkinson
Institution	University of York
Department	Chemistry
Funding type	Research
Value (£)	200,000
Status	Completed
Type	Research Grant
Start date	01/04/2003
End date	30/09/2003
Duration	6 months

Abstract

This application seeks funds for a high performance 500 MHz spectrometer with cryo-probe technology. The instrument will dramatically expand the NMR facilities at York, and will facilitate a number of new initiatives while supporting core biochemical and biological projects. The justification for the instrument is placed firmly in the context of the need for increased sensitivity and the associated ability to rapidly screen and distinguish samples containing small amounts of biologically significant materials. Projects utilising the full capabilities of the new systems are outlined. The ultimate aim is to develop methods that will facilitate the in vivo monitoring of ligand binding, the transport of drugs or metabolites across cell membranes and the examination of protein surfaces. It should be noted that success in this area will enable key biologic systems to be probed with ten to one hundred thousand times the sensitivity of normal methods. These studies are novel and will generate several publications.

Summary

unavailable

Committee	Closed Committee - Biomolecular Sciences (BMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Research Equipment Initiative 2002 (REI) [2002]
Funding Scheme	X – not Funded via a specific Funding Scheme

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