Award details

Gene expression in response to biotic and abiotic stress

Reference	REI18465
Principal Investigator / Supervisor	Professor Alison Baker
Co-Investigators / Co-Supervisors	Prof. Howard Atkinson, Professor Noel Buckley, Professor Simon Carding, Dr Kenneth McDowall, Dr Mary Phillips-Jones, Professor Anthony Turner, Professor Ian Wood
Institution	University of Leeds
Department	Plant Biochemistry & Biotechnology
Funding type	Research
Value (£)	43,300
Status	Completed
Type	Research Grant
Start date	01/05/2003
End date	01/05/2004
Duration	12 months

Abstract

The ability to monitor changes in gene expression underpins the research of many groups in the Faculty of Biological Sciences at the University of Leeds and is a key aspect of post-genome science. The applicants and their collaborators, which include clinicians, pharmaceutical and agribusiness companies, are seeking to understand changes in gene expression in response to stress in a wide range of organisms. Their work addresses many of the themes and priorities set out by the BBSRC committees, the Government White Paper and Foresight. Fundamental understanding of stresses in mammals that lead to degenerative disease has considerable impact on the quality of human life. They also impose an increased burden on developed countries as life expectancy increases. In order to build on their existing projects and develop new areas all these groups require rapid, sensitive and quantitative techniques for the analysis of transcripts. In many cases the amount of material available is very limited and existing methodology such as virtual northerns and semi-quantitative PCR are either insufficiently sensitive or insufficiently quantitative or both. Real time PCR, using equipment requested would meet these needs and would complement existing facilities for analysis of gene expression including microarray and in vivo imaging facilities.

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Research Equipment Initiative 2002 (REI) [2002]
Funding Scheme	X – not Funded via a specific Funding Scheme

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