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A new biological mass spectrometry facility for the centre for chemical biology
Reference
REI18461
Principal Investigator / Supervisor
Professor Emma Raven
Co-Investigators /
Co-Supervisors
Professor Paul Cullis
,
Professor Ian EPERON
,
Professor Gordon Roberts
Institution
University of Leicester
Department
Chemistry
Funding type
Research
Value (£)
150,448
Status
Completed
Type
Research Grant
Start date
27/06/2003
End date
26/06/2005
Duration
24 months
Abstract
The objectives of this proposal are to establish a new, high throughput, biological mass spectrometry facility for the Centre for Chemical Biology. This facility will play an essential part in the development of chemical biology in the post-genomic era in Leicester by making it possible for us to take advantage of the speed and sensitivity of modern mass spectrometry in proteomics, in chemogenomics and in supporting structural biology, combinatorial chemistry, and the development of novel biocatalysts. The application involves a number of major projects within three major themes of Proteomics, Molecular Engineering of Proteins, and Combinatorial Chemistry and Chemogenomics. Specifically, the new facility will be used to study multiprotein complexes involved in the regulation of gene expression, and complexes of cytoskeletal proteins, to identify changes in protein expression in disease states and as a screening tool in directed evolution experiments aimed at the molecular engineering of redox proteins. It will also provide an essential supporting facility for our work in combinatorial chemistry and chemogenomics and in structural biology.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Research Equipment Initiative 2002 (REI) [2002]
Funding Scheme
X – not Funded via a specific Funding Scheme
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