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Research Development Fellow: Professor J H Lakey. Self-assembly of engineered membrane-protein arrays for ion channel biosensors and other nanotechnology applications

Reference	RDF16940
Principal Investigator / Supervisor	Professor Monica Hughes
Co-Investigators / Co-Supervisors
Institution	Newcastle University
Department	Inst for Cell and Molecular Biosciences
Funding type	Research
Value (£)	94,576
Status	Completed
Type	Fellowships
Start date	01/01/2002
End date	01/01/2005
Duration	36 months

Abstract

BBSRC Research Development Fellowships are designed to enable UK university academic staff to devote themselves full-time to independent research. This is achieved by providing funds to the department to relieve the fellow of all significant teaching and administrative duties. This fellowship is for Professor J H Lakey. Recent data has shown that porins can be directly and covalently self assembled onto gold surfaces with close to 2D crystal density whilst retaining their pore-function. Porins are ideal candidates for protein engineering. The first objective will be to develop thiolipid and porin components which will allow precise control of the conductivity and sensitivity for a simple and robust electronic ion channel biosensor. The project will then investigate some of the many opportunities provided by this technology including co-assembly with nucleic acids, expression of protein modules in the porin loops, higher order self-assembly, biocompatible surface engineering and micro-contact printing of proteins.

Summary

unavailable

Committee	Closed Committee - Engineering & Biological Systems (EBS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Fellowship - Research Development Fellowship (RDF) [1999-2010]
Funding Scheme	X – not Funded via a specific Funding Scheme

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