BBSRC Portfolio Analyser
Award details
Environmental stress quorum sensing and secondary metabolism regulation in Serratia
Reference
PRS12226
Principal Investigator / Supervisor
Professor George Salmond
Co-Investigators /
Co-Supervisors
Institution
University of Cambridge
Department
Biochemistry
Funding type
Research
Value (£)
195,330
Status
Completed
Type
Research Grant
Start date
10/01/2000
End date
10/01/2003
Duration
36 months
Abstract
We have sequenced the gene cluster encoding biosynthesis of the red-pigmented antibiotic, prodigiosin, in Serratia marcescens. We have mutants which show altered production of the pigment. Some of the corresponding mutations map to the biosynthetic locus; others are in regulatory genes. Of the latter class, some are affected in two component systems and novel genes. We will define the transcriptional organisation of the pig biosynthetic cluster - determining the number and extent of the transcriptional units. We will characterise the regulatory genes encoding products involved in pig gene transcription. We will dissect a new quorum sensing system linking cell density to a secondary metabolism control and we will investigate how various diverse environmental and physiological signals are transduced in molecular control of pigment biosynthesis in this bacterium.
Summary
unavailable
Committee
Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Prokaryotic Responses to Environmental Stress (PRS) [1999]
Funding Scheme
X – not Funded via a specific Funding Scheme
I accept the
terms and conditions of use
(opens in new window)
export PDF file
back to list
new search