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Characterisation of the Salmonella typhimurium extracytoplasmic stress response
Reference
PRS12222
Principal Investigator / Supervisor
Professor Mark Roberts
Co-Investigators /
Co-Supervisors
Institution
University of Glasgow
Department
Veterinary Pathology
Funding type
Research
Value (£)
177,776
Status
Completed
Type
Research Grant
Start date
01/02/2000
End date
21/04/2003
Duration
39 months
Abstract
The extracytoplasmic stress response (ESR) in S. typhimurium is regulated by 2 separate signal transduction pathways. One pathway is controlled by the alternative sigma factor, RpoE, and the second is mediated by the two-component regulator CpxAR. One gene that is critically important to survival against extracytoplasmic stress, HtrA, is regulated by both RpoE and CpxAR. The purpose of this proposal is: 1. to analyse the role of the ESR pathways in regulation of HtrA in response to the in vivo-relevant stress; 2. to determine why the HtrA homologue, HhoA, does not compensate for the loss of HtrA; 3. to analyse if the growth and metabolic defects of a S. typhimurium RpoE mutant are due to affects on the production of respiratory chain components; 4. to use the information in genome databases and improved methods of locating regulatory sequences to identify new RpoE regulated genes.
Summary
unavailable
Committee
Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Prokaryotic Responses to Environmental Stress (PRS) [1999]
Funding Scheme
X – not Funded via a specific Funding Scheme
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