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Autocrine control of starvation stress in Bacillus subtilis
Reference
PRS12213
Principal Investigator / Supervisor
Professor Michael Young
Co-Investigators /
Co-Supervisors
Institution
Aberystwyth University
Department
Inst of Biological, Environ & Rural Sci
Funding type
Research
Value (£)
211,012
Status
Completed
Type
Research Grant
Start date
01/06/2000
End date
01/12/2003
Duration
42 months
Abstract
Starvation is the most common form of stress to which micro-organisms are exposed in nature, and in many organisms starvation provokes dormancy. In the high G+C cohort of Gram-positive bacteria we have discovered that dormancy and growth in minimal media are controlled by autocrine growth factors (cytokines). Most recently, we have uncovered a gene family that encodes the cognate proteins in representatives of the low G+C cohort of Gram- positive bacteria. In this investigation we will (a) isolate and characterise the two gene products found in Bacillus subtilis, (b) characterise their physiological role in promoting bacterial growth, (c) identify the growth factor receptor.
Summary
unavailable
Committee
Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Prokaryotic Responses to Environmental Stress (PRS) [1999]
Funding Scheme
X – not Funded via a specific Funding Scheme
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