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Trehalose stress and sporulation in Streptomyces coelicolor
Reference
PRS12211
Principal Investigator / Supervisor
Professor Keith Chater
Co-Investigators /
Co-Supervisors
Institution
John Innes Centre
Department
Molecular Microbiology
Funding type
Research
Value (£)
176,468
Status
Completed
Type
Research Grant
Start date
12/01/2000
End date
12/01/2003
Duration
36 months
Abstract
The morphologically complex organism Streptomyces coelicolor invests probably at least 14 genes in partitioning glucose between the stress-protecting disaccharide trehalose, the storage polysaccharide glycogen, and central metabolism. We propose to study (a) the temporal and spatial control of a subset of these genes during development and in response to stress treatments, in the wild-type and selected developmental mutants; (b) the effects of these changes in gene expression, and of deleting or modifying the genes, on trehalose and glycogen levels, stress resistance and normal development. The results should give an unusually integrated view of the way that stress responses are built into normal biology and metabolism. They may also be relevant to carbon flux in relation to antibiotic production.
Summary
unavailable
Committee
Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Prokaryotic Responses to Environmental Stress (PRS) [1999]
Funding Scheme
X – not Funded via a specific Funding Scheme
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