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Quorum-sensing control of stationary phase adaptation and associated resistance to environmental stresses in Rhizobium leguminosarum
Reference
PRS12210
Principal Investigator / Supervisor
Professor J Downie
Co-Investigators /
Co-Supervisors
Institution
John Innes Centre
Department
Molecular Microbiology
Funding type
Research
Value (£)
155,804
Status
Completed
Type
Research Grant
Start date
10/07/2000
End date
10/10/2003
Duration
39 months
Abstract
The am of this study is to dissect out the molecular mechanisms involved in multiple traits including adaptation to stationary phase Rhizobium leguminosarum and the associated acquired resistance to multiple environmental stresses. The response mechanism is regulated by a cascade of four quorum-sensing regulons that produce multiple N-acyl homoserine lactones (AHLs). Characters regulated by this system include: stationary phase adaptation and survival; resistance to salt and several other stresses, and rhisosphere growth and legume nodulation. Using mutants defective for AHL production, genes induced by AHLs will be identified from a promoter library using to gfp. The identified genes will be characterised in detail and their role in adaptation to stress determined both in vitro and in association with legume roots.
Summary
unavailable
Committee
Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Prokaryotic Responses to Environmental Stress (PRS) [1999]
Funding Scheme
X – not Funded via a specific Funding Scheme
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