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Control of flagellar switching in response to environmental stimuli in Rhodobacter sphaeroides

Reference	PRS12205
Principal Investigator / Supervisor	Professor Renee Sockett
Co-Investigators / Co-Supervisors	Professor Judith Armitage
Institution	University of Nottingham
Department	Sch of Biosciences
Funding type	Research
Value (£)	193,122
Status	Completed
Type	Research Grant
Start date	01/11/1999
End date	01/11/2002
Duration	36 months

Abstract

Bacteria swim towards improving or away from stressful environments by biasing their normally random swimming direction in a tactile response. In E. coli environmental stimuli are transduced via phosphorylation of CheY protein which binds FliM on the flagellar motor causing changes in swimming direction. Unlike E. coli Rhodobacter has a single stop-start flagellum, with a single type of FliM, but 4 different CheYs. We will determine how these CheYs tactically control the flagellar motor by testing: a) binding of CheY** mutants that mimic CheY-P & real CheY-Ps to FliM and FliM peptide b) testing for the CheY suppressors of FliM mutations c) the role of 4 unique cys residues of FliM d) if altering expression levels of CheYs alters taxis.

Summary

unavailable

Committee	Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Prokaryotic Responses to Environmental Stress (PRS) [1999]
Funding Scheme	X – not Funded via a specific Funding Scheme

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