Award details

Responding to population density-dependent stress: quorum sensing and multicellular behaviour in Vibrio anguillarum

ReferencePRS12200
Principal Investigator / Supervisor Professor Paul Williams
Co-Investigators /
Co-Supervisors
Professor Miguel Camara, Dr Andrea Hardman
Institution University of Nottingham
DepartmentSch of Pharmacy
Funding typeResearch
Value (£) 177,812
StatusCompleted
TypeResearch Grant
Start date 01/11/1999
End date 28/03/2003
Duration41 months

Abstract

In V. anguillarum, we have uncovered a multi-layered quorum sensing system in which two circuits converge to drive expression of a third circuit involved in the control of biofilm development. Two of the systems depend on N-acylhomoserine lactones which the third employs an as yet unidentified polar molecular. We propose to build on these preliminary observations by (1) determining the nature of the polar molecule and its corresponding synthase; (2) identifying the target genes regulated by quorum sensing; (3) obtaining direct biochemical evidence for the phosphorylation of key regulatory proteins and (4) determining whether the cellular location of the key proteins are consistent with the proposed model for quorum sensing in V. anguillarum.

Summary

unavailable
Committee Closed Committee - Plant & Microbial Sciences (PMS)
Research TopicsX – not assigned to a current Research Topic
Research PriorityX – Research Priority information not available
Research Initiative Prokaryotic Responses to Environmental Stress (PRS) [1999]
Funding SchemeX – not Funded via a specific Funding Scheme
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