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Responding to population density-dependent stress: quorum sensing and multicellular behaviour in Vibrio anguillarum
Reference
PRS12200
Principal Investigator / Supervisor
Professor Paul Williams
Co-Investigators /
Co-Supervisors
Professor Miguel Camara
,
Dr Andrea Hardman
Institution
University of Nottingham
Department
Sch of Pharmacy
Funding type
Research
Value (£)
177,812
Status
Completed
Type
Research Grant
Start date
01/11/1999
End date
28/03/2003
Duration
41 months
Abstract
In V. anguillarum, we have uncovered a multi-layered quorum sensing system in which two circuits converge to drive expression of a third circuit involved in the control of biofilm development. Two of the systems depend on N-acylhomoserine lactones which the third employs an as yet unidentified polar molecular. We propose to build on these preliminary observations by (1) determining the nature of the polar molecule and its corresponding synthase; (2) identifying the target genes regulated by quorum sensing; (3) obtaining direct biochemical evidence for the phosphorylation of key regulatory proteins and (4) determining whether the cellular location of the key proteins are consistent with the proposed model for quorum sensing in V. anguillarum.
Summary
unavailable
Committee
Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Prokaryotic Responses to Environmental Stress (PRS) [1999]
Funding Scheme
X – not Funded via a specific Funding Scheme
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