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Bacterial responses to nitric oxide (NO) and nitrosative stresses

Reference	PRS12199
Principal Investigator / Supervisor	Professor Robert K Poole
Co-Investigators / Co-Supervisors	Dr Hugo Cruz-Ramos, Professor M Hughes
Institution	University of Sheffield
Department	Molecular Biology and Biotechnology
Funding type	Research
Value (£)	218,160
Status	Completed
Type	Research Grant
Start date	08/12/1999
End date	01/08/2003
Duration	44 months

Abstract

Nitric acid (NO) is one of the most important small molecules in biology. We propose, using Escherichia coli as a model system, to understand the only well-established bacterial NO resistance mechanism - mediated by the flavohaemoglobin, Hmp - by determining the contribution of Hmp aerobically and anaerobically to NO and nitrosative stress responses and the molecular mechanisms of hmp up-regulation and NO detoxification. We will also seek other responses to NO and nitrosative stress at gene and protein levels to determine which genes are up-regulated by these stresses, what genes govern tolerance and sensitivity, and identify cellular targets. The project will contribute to a holistic understanding of how other bacteria survive NO and nitrosative stress in environments such as foods, plant and animal hosts, and soils.

Summary

unavailable

Committee	Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Prokaryotic Responses to Environmental Stress (PRS) [1999]
Funding Scheme	X – not Funded via a specific Funding Scheme

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