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The role of an FNR-related transcription regulator protein in the survival of pathogenic Neisseria

Reference	PRS12198
Principal Investigator / Supervisor	Professor Jeffrey Cole
Co-Investigators / Co-Supervisors	Professor Steve Busby
Institution	University of Birmingham
Department	Sch of Biosciences
Funding type	Research
Value (£)	186,128
Status	Completed
Type	Research Grant
Start date	01/03/2000
End date	01/04/2003
Duration	37 months

Abstract

The aims of this project are to determine the role of FNR in the survival of pathogenic neisseria during oxygen starvation, to characterise the FNR regulon in neisseria, and to understand the molecular architecture of neisserial FNR and FNR-dependent promoters. We propose to determine (i) whether the gonococcal FNR-like protein is essential for adaptation to oxygen-limited growth, (ii) what genes are regulated by the gonococcal FNR- like protein and how their cognate promoters are organised (iii) whether a gonococcal fnr mutant is defective in pathogenicity, (iv) how the gonococcal FNR-like protein interfaces with the different subunits of RNA polymerase, (v) whether gonococcal promoters regulated by the FNR-like protein are also regulated by a NarP homologue, (vi) how such promoters are organised, and whether a gonococcal NarP regulon can be identified, (vii) whether meningococci have similar mechanisms for surviving during oxygen starvation, (viii) how gonococci reduce nitric oxide and how this process is regulated, and (ix) whether the stress response ? factor, ?32, is essential for gonococcal growth. The results will reveal how pathogenic neisseria regulate gene expression in response to environmental stress and the importance of this regulation for survival during oxygen starvation.

Summary

unavailable

Committee	Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Prokaryotic Responses to Environmental Stress (PRS) [1999]
Funding Scheme	X – not Funded via a specific Funding Scheme

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